Dr. Elizabeth Norton and her research team are part of the Tulane School of Medicine Department of Microbiology & Immunology. Our research focuses on how to promote a healthy immune system. We are interested in how immunity can be manipulated against acute infections or during chronic inflammatory diseases, particularly for mucosal surfaces. Ongoing areas of research include: (1) the ADP-ribosylation enterotoxin proteins derived from heat-labile toxin of E. coli (LT) as adjuvants for vaccines to promote protective immunity (against flu, TB, Polio, ETEC diseases), (2) how inflammation or disease alters age-related immunity and vaccine efficacy, and (3) whether novel derivatives of LT that dampen inflammation can function as a unique inflammatory bowel disease (IBD) therapy. The links in the toolbar have more information about us and our research, but below, you can find a little more about the why, how, & what of the research we do.
Why
Why do we research what we do? The host immune system is dynamic and complex. If we can understand how to manipulate immunity, we can improve human health.
How
How do we investigate imunological questions? Through tissue culture, animal models, & primary human samples. Some of our project specific assays include protein (gels, blots, ELISAs, bioplex); signaling (microscopy, WB, IP); cellular characterizations (microscopy, flow, culture); site-specific or mucosal surface; bacterial, viral or disease-specific.
What
What is the focus of our research? A major focus is immunomodulation through vaccines or therapeutics against disease (Influenza, ETEC, IBD). We also investigate the impact of age or underlying chronic disease (IBD, diabetes) on immunologic function.
A minireview by Dr. Elizabeth “Betzi” Norton and long-time collaborator Dr. John Clements entitled “The Mucosal Vaccine Adjuvant LT(R192G/L211A) or dmLT” has recently been published…
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The Broad Medical Research Program at the Crohn’s & Colitis Foundation of America has extended their Inflammatory Bowel Disease Grant to Norton Lab for a second year. The…
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In May, members of Norton Lab flew to Seattle for the American Association of Immunologists (AAI) 2016 Annual Meeting at the Washington State Convention Center. In…
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This was a busy fall for Norton Lab! We received an NIH RO1 grant for testing the efficacy of new generation proteins, LTA and LTA1, as…
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According to the CDC, everyone 6 months and older should get the annual flu vaccination, with rare exception (1). Influenza is a serious disease that can lead…
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On October 28th, WGNO swung by Norton Lab to talk to interview Dr. Norton about her $1.6 million NIH grant to develop new adjuvants for…
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Do you want to make an impact in your community? Do you want to be a part of defining future healthcare for others? Do you…
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